I. Technical Specifications
- Molecular Formula: C_26H_22F_3N_3O_3S
- Molecular Weight: 513.5 g/mol
- CAS Number: 2938722-17-7
- Appearance: White to Off-White Lyophilized Powder
- Solubility: Soluble in DMSO or Ethanol (limited solubility in standard Bacteriostatic Water; researchers often utilize a co-solvent for in-vitro studies).
II. Compound Overview
SLU-PP-332
is a first-in-class ERR agonist
known in research for its role as an “exercise mimetic.”
Unlike traditional metabolic peptides that target incretin receptors, SLU-PP-332 acts directly on the genetic transcription factors that govern oxidative metabolism. In laboratory models, it has demonstrated a unique capacity to induce the physiological benefits of aerobic exercise
without physical exertion. Taurus Peptides provides this compound as a highly purified, vacuum-sealed powder to ensure maximum stability for studies involving metabolic flux and skeletal muscle adaptation.
III. Mechanism of Action (The “Science” Section)
Current literature suggests that SLU-PP-332
functions primarily by activating the Estrogen-Related Receptor (ERR) family
, specifically ERR\alpha, ERR\beta, and ERR\gamma. Researchers observe that this mechanism leads to the upregulation of a gene expression program typically triggered by endurance exercise.
Unlike compounds that focus solely on glucose disposal, SLU-PP-332 demonstrates high affinity for PGC-1\alpha signaling pathways
, making it a primary candidate for studies involving mitochondrial biogenesis and fatty acid oxidation.
By increasing the density and efficiency of mitochondria within skeletal muscle, it allows researchers to observe shifts in systemic energy expenditure and “fuel switching” from glucose to lipid metabolism.
IV. Observed Research Outcomes
- Enhanced Endurance: Studies observed a significant increase (up to 45%) in treadmill running distance in rodent models following sustained administration.
- Adiposity Reduction: Research indicates a marked decrease in fat mass and improved insulin sensitivity, even in models maintained on high-fat diets.
- Mitochondrial Density: When evaluated in muscle tissue assays, researchers noted a statistically significant increase in mitochondrial DNA markers and oxidative enzyme activity.
V. Storage & Handling
- Storage: Lyophilized SLU-PP-332 should be stored at -20^\circ C for long-term stability.
- Handling: Avoid direct light exposure and moisture. Because SLU-PP-332 has different solubility profiles than standard peptides, it is recommended to reconstitute using a laboratory-grade solvent like DMSO before further dilution into aqueous buffers for research applications.
