I. Technical Specifications
- Molecular Formula: C_37 H_51 N_9 O_10 S
- Molecular Weight: 813.93 g/mol
- CAS Number: 80714-61-0
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Appearance: White Lyophilized Powder
- Solubility: Soluble in Bacteriostatic Water or Sterile Water
II. Compound Overview
Semax
is a heptapeptide
known in research for its profound nootropic and neuroprotective properties.
Originally developed as a synthetic analog of adrenocorticotropic hormone (ACTH), it was engineered to be entirely devoid of hormonal activity while retaining potent regulatory effects on the central nervous system. In laboratory models, the addition of the Pro-Gly-Pro tripeptide to the C-terminus has demonstrated a unique capacity to resist peptidase degradation
, significantly extending its biological activity compared to its parent fragments. Taurus Peptides provides this compound as a highly purified, vacuum-sealed powder to ensure maximum stability for in-vitro and in-vivo neurological research.
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III. Mechanism of Action (The “Science” Section)
Current literature suggests that Semax
functions primarily by modulating the expression of neurotrophins and their receptors
, most notably Brain-Derived Neurotrophic Factor (BDNF) and TrkB. Researchers observe that this mechanism leads to the enhancement of synaptic plasticity and neuronal survival
under conditions of metabolic or oxidative stress.
Unlike traditional stimulants, Semax
demonstrates high affinity for melanocortin receptors (MC4 and MC5)
, acting as a competitive antagonist or partial agonist. This unique receptor profile allows for the study of its influence on the dopaminergic and serotonergic systems
, where it has been shown to increase neurotransmitter turnover. Furthermore, recent genomic studies indicate that Semax can influence the transcription of over 1,000 genes, particularly those involved in the immune response and vascular integrity during ischemic events.
IV. Observed Research Outcomes
- Neurotrophic Upregulation: Studies observed a rapid increase in BDNF levels in the hippocampus within 3 hours of administration in animal models.
- Anti-Inflammatory Modulation: Research indicates a statistically significant decrease in the mRNA levels of pro-inflammatory cytokines such as IL-1\alpha, IL-1\beta, and IL-6.
- Ischemic Resilience: When evaluated in stroke models, researchers noted a reduction in infarct size and improved neurological recovery scores compared to control groups.
V. Storage & Handling
- Storage: Lyophilized peptides should be stored at −20∘C. Once reconstituted, store at 4∘C for up to 14 days.
- Handling: Avoid agitation/shaking of the vial after reconstitution to prevent degradation of the peptide chain. Because the sequence contains Methionine (M), it is particularly prone to oxidation; researchers should minimize exposure to air and ensure the vial is tightly sealed between uses. Equilibrate the vial to room temperature before opening to prevent moisture condensation on the powder.
