- Molecular Formula: C_50 H_69 N_15 O_9
- Molecular Weight: 1024.2 g/mol
- CAS Number: 121062-08-6
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
- Appearance: White Lyophilized Powder
- Solubility: Soluble in Bacteriostatic Water
Compound Overview
Melanotan-2 (MTII) is a cyclic heptapeptide known in research for its potent, non-selective agonism of melanocortin receptors. As a synthetic analog of endogenous \alpha-MSH, it has demonstrated a unique capacity to stimulate protective pigmentation in laboratory models. Taurus Peptides provides this compound as a highly purified, vacuum-sealed powder to ensure maximum stability for in-vitro and in-vivo research concerning dermatology and energy homeostasis.
Mechanism of Action (The “Science” Section)
Current literature suggests that MTII functions primarily by mimicking the action of melanocyte-stimulating hormones across several receptor subtypes, most notably MC1R, MC3R, and MC4R. Researchers observe that this mechanism leads to the upregulation of eumelanin production within melanocytes via the MC1R pathway.
Unlike other compounds, MTII demonstrates high affinity for MC4R receptors in the hypothalamus, making it a primary candidate for studies involving appetite regulation, thermogenesis, and sexual behavior. By crossing the blood-brain barrier, MTII allows researchers to observe the complex interplay between peripheral pigmentation and central nervous system metabolic control.
Observed Research Outcomes
- Melanogenesis Stimulation: Studies observed a significant increase in melanin density in animal models following sustained administration intervals.
- Metabolic Impact: Research indicates a notable influence on lipid metabolism and food intake reduction in models focused on MC4R activation.
- Synergistic Potential: When evaluated alongside PT-141, researchers noted that while MTII shares the same core structure, its C-terminal amide contributes to a broader range of receptor activation, including integumentary responses.
Storage & Handling
- Storage: Lyophilized peptides should be stored at -20^\circ C. Once reconstituted, store at 4^\circ C for up to 14 days to maintain peptide integrity.
Handling: Avoid agitation/shaking of the vial after reconstitution to prevent degradation of the peptide chain. It is recommended to use a gentle swirling motion when mixing with bacteriostatic water.
