I. Technical Specifications
- Molecular Formula: C_14H_22N_4O_9
- Molecular Weight: 390.35 g/mol
- CAS Number: 307297-39-8
- Sequence: Ala-Glu-Asp-Gly
- Appearance: White Lyophilized Powder
- Solubility: Highly soluble in Water or Bacteriostatic Water
II. Compound Overview
Epitalon
is a short-chain tetrapeptide
known in research as a “geroprotector.” Originally discovered at the St. Petersburg Institute of Bioregulation and Gerontology, it was designed to mimic the biological effects of Epithalamin
, a pineal gland extract. In laboratory models, Epitalon has demonstrated a unique capacity to cross the cellular membrane
and interact directly with DNA. Taurus Peptides provides this compound as a highly purified, vacuum-sealed powder in 10mg and 30mg
formats, specifically for longitudinal studies regarding the biological clock and genomic stability.
III. Mechanism of Action (The “Science” Section)
Current literature suggests that Epitalon
functions primarily as a telomerase activator.
Telomerase is the enzyme responsible for maintaining and elongating telomeres—the protective caps on the ends of chromosomes. Researchers observe that by stimulating the TERT (Telomerase Reverse Transcriptase) gene
, Epitalon may help overcome the “Hayflick Limit,” the point at which a cell can no longer divide.
Furthermore, Epitalon is evaluated for its ability to restore pineal gland function.
It is thought to increase the gland’s sensitivity to light-dark cycles, thereby optimizing the endogenous synthesis of melatonin
. Unlike direct melatonin administration, Epitalon acts at the level of peptide-DNA interaction, regulating the expression of genes involved in antioxidant defense and circadian rhythm synchronization.
IV. Observed Research Outcomes
- Telomere Elongation: Studies observed a significant increase in telomere length in human somatic cells in-vitro after administration of Epitalon.
- Longevity Signaling: Research indicates that Epitalon significantly extended the maximum lifespan and reduced the incidence of spontaneous tumors in rodent models.
- Circadian Restoration: When evaluated in aging models, researchers noted that Epitalon helped normalize the secretion of melatonin and cortisol, effectively “re-syncing” the biological clock.
V. Storage & Handling
- Storage: Lyophilized Epitalon is extremely stable. Store at -20^\circ C for long-term stability. Once reconstituted, store at 4^\circ C and use within 14–21 days.
- Handling: Epitalon is a robust tetrapeptide. Reconstitute with a sterile, pH-neutral diluent like Bacteriostatic Water. Allow the lyophilized cake to fully dissolve by gently swirling the vial. Avoid harsh agitation, though the molecule is less fragile than larger proteins like IGF-1.
