I. Technical Specifications
- Molecular Formula: C_10H_11IN_2 (as Iodide salt)
- Molecular Weight: 286.11 g/mol
- CAS Number: 42464-96-0
- Sequence: N/A (Small Molecule)
- Appearance: Faint red to dark brown crystalline powder
- Solubility: Soluble in DMSO (2 mg/mL) or Bacteriostatic Water (10 mg/mL)
II. Compound Overview
5-Amino-1MQ
(5-amino-1-methylquinolinium) is a selective, cell-permeable NNMT inhibitor
known in research for its potent metabolic-regulatory properties.
Unlike traditional peptides, this small molecule targets the NNMT enzyme, which is primarily upregulated in white adipose tissue and the liver during metabolic dysfunction. In laboratory models, 5-Amino-1MQ has demonstrated a unique capacity to block the degradation of nicotinamide
, thereby increasing the availability of precursors for NAD+ synthesis. Taurus Peptides provides this compound as a highly purified powder to ensure maximum structural integrity for in-vitro and in-vivo metabolic research.
III. Mechanism of Action (The “Science” Section)
Current literature suggests that 5-Amino-1MQ
functions primarily by competitively inhibiting Nicotinamide N-methyltransferase (NNMT).
NNMT typically catalyzes the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA). Researchers observe that high levels of NNMT “trap” nicotinamide, preventing it from being recycled into NAD+.
By inhibiting this enzyme, 5-Amino-1MQ effectively increases intracellular NAD+ and SAM levels.
Researchers observe that this mechanism leads to the activation of sirtuins and the upregulation of GLUT4 transporters
, making it a primary candidate for studies involving glucose clearance, fatty acid oxidation, and mitochondrial efficiency.
Unlike systemic stimulants, 5-Amino-1MQ targets the root enzymatic cause of metabolic slowing within the adipocyte (fat cell) itself.
IV. Observed Research Outcomes
- Adipose Tissue Remodeling: Studies observed a significant reduction in adipocyte hypertrophy and lipogenesis in high-fat diet models without affecting food intake.
- Skeletal Muscle Performance: Research indicates a 60% increase in contractile force and enhanced grip strength in aged rodent models, attributed to improved muscle quality and reduced lipid accumulation.
- NAD+ Optimization: In-vitro assays have shown that NNMT inhibition directly correlates with a surge in cellular NAD+ concentrations, supporting mitochondrial longevity and DNA repair pathways.
V. Storage & Handling
- Storage: Store at -20^\circ C in a cool, dry place. Keep protected from direct light, as the quinolinium structure can be light-sensitive over long durations.
- Handling: Equilibrate the vial to room temperature before opening to avoid condensation. 5-Amino-1MQ is stable in powder form but should be used promptly once reconstituted in a solution. For research requiring high concentrations, DMSO is the preferred primary solvent.
